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A Metabolomics Profiling Study in Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention Using Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry
Joint Authors
Lu, Cheng
Xie, Ning
Chen, Xiao
Ko, Joshua K.
Ding, Xiaorong
Zhang, Weidong
Fan, Haiwei
Liu, Xinru
Lu, Ai-ping
Liu, Yunqiang
Tan, Yong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hand-foot-and-mouth disease (HFMD), with poorly understood pathogenesis, has become a major public health threat across Asia Pacific.
In order to characterize the metabolic changes of HFMD and to unravel the regulatory role of clinical intervention, we have performed a metabolomics approach in a clinical trial.
In this study, metabolites profiling was performed by liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) platform from the HFMD clinical patient samples.
The outcome of this study suggested that 31 endogenous metabolites were mainly involved and showed marked perturbation in HFMD patients.
In addition, combination therapy intervention showed normalized tendency in HFMD patients in differential pathway.
Taken together, these results indicate that metabolomics approach can be used as a complementary tool for the detection and the study of the etiology of HFMD.
American Psychological Association (APA)
Lu, Cheng& Liu, Xinru& Ding, Xiaorong& Chen, Xiao& Fan, Haiwei& Liu, Yunqiang…[et al.]. 2013. A Metabolomics Profiling Study in Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention Using Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-487940
Modern Language Association (MLA)
Lu, Cheng…[et al.]. A Metabolomics Profiling Study in Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention Using Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-487940
American Medical Association (AMA)
Lu, Cheng& Liu, Xinru& Ding, Xiaorong& Chen, Xiao& Fan, Haiwei& Liu, Yunqiang…[et al.]. A Metabolomics Profiling Study in Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention Using Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-487940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487940