Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics : A Study with the General Practice Research Database
Joint Authors
Shatapathy, Chetan C.
Brunner, Elizabeth
Jones, Meghan E.
van Staa, Tjeerd P.
Motsko, Stephen
Patel, Deven
Murray-Thomas, Tarita
Campbell, Giedra
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
Assess risk of cardiac events and mortality among users of olanzapine and other antipsychotics relative to nonusers.
Methods.
The General Practice Research Database was used to identify cohorts of antipsychotic users and nonusers with psychiatric illness.
Outcomes included cardiac mortality, sudden cardiac death (SCD), all-cause mortality (excluding suicide), coronary heart disease (CHD), and ventricular arrhythmias (VA).
Results.
183,392 antipsychotic users (including 20,954 olanzapine users) and 193,920 psychiatric nonusers were identified.
There was a significantly higher rate of cardiac mortality (adjusted RR [aRR]: 1.53, CI, 1.12–2.09) in olanzapine users relative to psychiatric nonusers, consistent with findings for both atypical and typical antipsychotics.
Relative to psychiatric nonusers, no increased risk of all-cause mortality was observed among olanzapine users (aRR: 1.04, CI, 0.93–1.17), but elevated all-cause mortality risk was observed when compared to all antipsychotic users (aRR: 1.75, CI, 1.64–1.87).
There was no increased risk of CHD or VA among olanzapine users relative to psychiatric nonusers, consistent with findings for atypical but not typical antipsychotics.
SCD cases were uncommon.
Conclusions.
Use of antipsychotic agents was associated with increased risk of all-cause and cardiac mortality.
Patients treated with olanzapine were found to be at increased risk of cardiac mortality versus psychiatric nonusers.
American Psychological Association (APA)
Jones, Meghan E.& Campbell, Giedra& Patel, Deven& Brunner, Elizabeth& Shatapathy, Chetan C.& Murray-Thomas, Tarita…[et al.]. 2013. Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics : A Study with the General Practice Research Database. Cardiovascular Psychiatry and Neurology،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-487942
Modern Language Association (MLA)
Jones, Meghan E.…[et al.]. Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics : A Study with the General Practice Research Database. Cardiovascular Psychiatry and Neurology No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-487942
American Medical Association (AMA)
Jones, Meghan E.& Campbell, Giedra& Patel, Deven& Brunner, Elizabeth& Shatapathy, Chetan C.& Murray-Thomas, Tarita…[et al.]. Risk of Mortality (including Sudden Cardiac Death) and Major Cardiovascular Events in Users of Olanzapine and Other Antipsychotics : A Study with the General Practice Research Database. Cardiovascular Psychiatry and Neurology. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-487942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487942