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Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C : Implication of β1-Integrin Activation
Joint Authors
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cell adhesion to extracellular matrix (ECM) participates in various biological processes, such as cell survival, proliferation, differentiation, and migration.
Since these processes are essential for keeping homeostasis, aberration of these processes leads to a variety of diseases including cancer.
Previously, we found that a peptide derived from tenascin- (TN-) C, termed TNIIIA2, stimulates cell adhesion to ECM through activation of β1-integrin.
It has been shown that TNIIIA2 can modulate cell proliferation and differentiation.
Interestingly, TNIIIA2 could not only enhance cell proliferation but also induce apoptotic cell death, depending on cellular context.
In this review, we show the function of the peptide TNIIIA2 in cell survival, proliferation, and differentiation and refer to the possibility of new strategy for tumor suppression by regulating cell adhesion status using the ECM-derived functional peptides.
American Psychological Association (APA)
Iyoda, Takuya& Fukai, Fumio. 2011. Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C : Implication of β1-Integrin Activation. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-487956
Modern Language Association (MLA)
Iyoda, Takuya& Fukai, Fumio. Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C : Implication of β1-Integrin Activation. International Journal of Cell Biology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-487956
American Medical Association (AMA)
Iyoda, Takuya& Fukai, Fumio. Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C : Implication of β1-Integrin Activation. International Journal of Cell Biology. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-487956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487956