A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats
Joint Authors
Lam, Virginie
Galloway, Susan
Mamo, John C. L.
Pallebage-Gamarallage, Menuka M.
Takechi, Ryusuke
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chronic ingestion of saturated fatty acids (SFAs) was previously shown to compromise blood-brain barrier integrity, leading to brain parenchymal extravasation of apolipoprotein B (apo B) lipoproteins enriched in amyloid beta.
In contrast, diets enriched in mono- or polyunsaturated (PUFA) oils had no detrimental effect.
Rather, n3 and n6 oils generally confer protection via suppression of inflammation.
This study investigated in wild-type mice if a PUFA diet enriched in docosahexanoic acid (DHA) restored blood-brain barrier integrity and attenuated parenchymal apo B abundance induced by chronic ingestion of SFA.
Cerebrovascular leakage of apo B was quantitated utilising immunofluorescent staining.
The plasma concentration of brain-derived S100β was measured as a marker of cerebrovascular inflammation.
In mice fed SFA for 3 months, provision thereafter of a DHA-enriched diet exacerbated parenchymal apo B retention, concomitant with a significant increase in plasma cholesterol.
In contrast, provision of a low-fat diet following chronic SFA feeding had no effect on SFA-induced parenchymal apo B.
The findings suggest that in a heightened state of cerebrovascular inflammation, the provision of unsaturated fatty acids may be detrimental, possibly as a consequence of a greater susceptibility for oxidation.
American Psychological Association (APA)
Pallebage-Gamarallage, Menuka M.& Lam, Virginie& Takechi, Ryusuke& Galloway, Susan& Mamo, John C. L.. 2011. A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487965
Modern Language Association (MLA)
Pallebage-Gamarallage, Menuka M.…[et al.]. A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats. International Journal of Vascular Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-487965
American Medical Association (AMA)
Pallebage-Gamarallage, Menuka M.& Lam, Virginie& Takechi, Ryusuke& Galloway, Susan& Mamo, John C. L.. A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats. International Journal of Vascular Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-487965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487965