Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease : The RUN DMC Study
Joint Authors
Tendolkar, I.
de Laat, K. F.
Zwiers, M. P.
van Norden, A. G. W.
van Uden, I. W. M.
van Oudheusden, L. J. B.
de Leeuw, Frank-Erik
Gons, R. A. R.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Introduction.
Late onset depressive symptoms (LODSs) frequently occur in elderly with cerebral small vessel disease (SVD).
SVD cannot fully explain LODS; a contributing factor could be amygdala volume.
We investigated the relation between amygdala volume and LODS, independent of SVD in 503 participants with symptomatic cerebral SVD.
Methods.
Patients underwent FLAIR and T1 scanning.
Depressive symptoms were assessed with structured questionnaires; amygdala and WML were manually segmented.
The relation between amygdala volume and LODS/EODS was investigated and adjusted for age, sex, intracranial volume, and SVD.
Results.
Patients with LODS had a significantly lower left amygdala volume than those without (P=0.02), independent of SVD.
Each decrease of total amygdala volume (by mL) was related to an increased risk of LODS (OR=1.77; 95% CI 1.02–3.08; P=0.04).
Conclusion.
Lower left amygdala volume is associated with LODS, independent of SVD.
This may suggest differential mechanisms, in which individuals with a small amygdala might be vulnerable to develop LODS.
American Psychological Association (APA)
van Uden, I. W. M.& van Norden, A. G. W.& de Laat, K. F.& van Oudheusden, L. J. B.& Gons, R. A. R.& Tendolkar, I.…[et al.]. 2011. Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease : The RUN DMC Study. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-487974
Modern Language Association (MLA)
van Uden, I. W. M.…[et al.]. Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease : The RUN DMC Study. Journal of Aging Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-487974
American Medical Association (AMA)
van Uden, I. W. M.& van Norden, A. G. W.& de Laat, K. F.& van Oudheusden, L. J. B.& Gons, R. A. R.& Tendolkar, I.…[et al.]. Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease : The RUN DMC Study. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-487974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487974