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Antioxidant and Hepatoprotective Effects of Silibinin in a Rat Model of Nonalcoholic Steatohepatitis
Joint Authors
Brault, Antoine
Haddad, Yara
Haddad, Pierre S.
Vallerand, Diane
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nonalcoholic steatohepatitis (NASH) is a progressive liver disease related to the metabolic syndrome, obesity and diabetes.
The rising prevalence of NASH and the lack of efficient treatments have led to the exploration of different therapeutic approaches.
Milk thistle (Silibum marianum) is a medicinal plant used for its hepatoprotective properties in chronic liver disease since the 4th century BC.
We explored the therapeutic effect of silibinin, the plant's most biologically active extract, in an experimental rat NASH model.
A control group was fed a standard liquid diet for 12 weeks.
The other groups were fed a high-fat liquid diet for 12 weeks without (NASH) or with simultaneous daily supplement with silibinin–phosphatidylcholine complex (Silibinin 200 mg kg−1) for the last 5 weeks.
NASH rats developed all key hallmarks of the pathology.
Treatment with silibinin improved liver steatosis and inflammation and decreased NASH-induced lipid peroxidation, plasma insulin and TNF-α.
Silibinin also decreased O2∙- release and returned the relative liver weight as well as GSH back to normal.
Our results suggest that milk thistle's extract, silibinin, possesses antioxidant, hypoinsulinemic and hepatoprotective properties that act against NASH-induced liver damage.
This medicinal herb thus shows promising therapeutic potential for the treatment of NASH.
American Psychological Association (APA)
Haddad, Yara& Vallerand, Diane& Brault, Antoine& Haddad, Pierre S.. 2011. Antioxidant and Hepatoprotective Effects of Silibinin in a Rat Model of Nonalcoholic Steatohepatitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-487977
Modern Language Association (MLA)
Haddad, Yara…[et al.]. Antioxidant and Hepatoprotective Effects of Silibinin in a Rat Model of Nonalcoholic Steatohepatitis. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-487977
American Medical Association (AMA)
Haddad, Yara& Vallerand, Diane& Brault, Antoine& Haddad, Pierre S.. Antioxidant and Hepatoprotective Effects of Silibinin in a Rat Model of Nonalcoholic Steatohepatitis. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-487977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-487977