Overview of Hepatocellular Adenoma in Japan
Joint Authors
Sasaki, Motoko
Nakanuma, Yasuni
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hepatocellular adenoma (HCA) is generally a benign hepatocellular tumor arising in a nonfibrotic/cirrhotic liver, and recently four major subgroups were identified based on genotype and phenotype classification from Europe.
HCA is rare in Asian countries including Japan, and there have been few studies regarding the subgroups of HCA in Japan.
We surveyed subgroups of HCA in 13 patients (7 women) in Japan, based on the phenotypic classification.
As results, we identified 2 hepatocyte nuclear factor (HNF) 1α-inactivated HCAs (15%), two β-catenin-activated HCAs (15%), 5 inflammatory HCAs (39%), and 4 unclassified HCAs (29%).
The use of oral contraceptives was found only in 2 unclassified HCAs (29%).
Rather low percentage of female patients and use of oral contraceptives appear to be common clinicopathological features in Japan and also East Asian countries.
Furthermore, a group of possible inflammatory HCAs characterized by strong immunoreactivity for serum amyloid A (SAA) was found in patients with alcoholic cirrhosis.
The inflammatory HCA/SAA-positive hepatocellular neoplasm in alcoholic cirrhosis may be a new entity of HCA, which may have potential of malignant transformation.
Further studies are needed to clarify genetic changes, monoclonality, and pathogenesis of this new type of hepatocellular neoplasm.
American Psychological Association (APA)
Sasaki, Motoko& Nakanuma, Yasuni. 2012. Overview of Hepatocellular Adenoma in Japan. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488000
Modern Language Association (MLA)
Sasaki, Motoko& Nakanuma, Yasuni. Overview of Hepatocellular Adenoma in Japan. International Journal of Hepatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-488000
American Medical Association (AMA)
Sasaki, Motoko& Nakanuma, Yasuni. Overview of Hepatocellular Adenoma in Japan. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488000