Analyzing Association of the XRCC3 Gene Polymorphism with Ovarian Cancer Risk

Abstract EN

This meta-analysis aims to examine whether the XRCC3 polymorphisms are associated with ovarian cancer risk.

Eligible case-control studies were identified through search in PubMed.

Pooled odds ratios (ORs) were appropriately derived from fixed effects models.

We therefore performed a meta-analysis of 5,302 ovarian cancer cases and 8,075 controls from 4 published articles and 8 case-control studies for 3 SNPs of XRCC3.

No statistically significant associations between XRCC3 rs861539 polymorphisms and ovarian cancer risk were observed in any genetic models.

For XRCC3 rs1799794 polymorphisms, we observed a statistically significant correlation with ovarian cancer risk using the homozygote comparison (T2T2 versus T1T1: OR = 0.70, 95% CI = 0.54–0.90, P=0.005), heterozygote comparison (T1T2 versus T1T1: OR = 1.10, 95% CI = 1.00–1.21, P=0.04), and the recessive genetic model (T2T2 versus T1T1+T1T2: OR = 0.67, 95% CI = 0.52–0.87, P=0.002).

For XRCC3 rs1799796 polymorphisms, we also observed a statistically significant correlation with ovarian cancer risk using the heterozygote comparison (T1T2 versus T1T1: OR = 0.91, 95% CI = 0.83–0.99, P=0.04).

In conclusion, this meta-analysis shows that the XRCC3 were associated with ovarian cancer risk overall for Caucasians.

Asian and African populations should be further studied.