The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease
Joint Authors
Koeller, Carolina Macedo
Heise, Norton
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The protozoan parasite Trypanosoma cruzi is the causative agent of human Chagas disease, for which there currently is no cure.
The life cycle of T.
cruzi is complex, including an extracellular phase in the triatomine insect vector and an obligatory intracellular stage inside the vertebrate host.
These phases depend on a variety of surface glycosylphosphatidylinositol-(GPI-) anchored glycoconjugates that are synthesized by the parasite.
Therefore, the surface expression of GPI-anchored components and the biosynthetic pathways of GPI anchors are attractive targets for new therapies for Chagas disease.
We identified new drug targets for chemotherapy by taking the available genome sequence information and searching for differences in the sphingolipid biosynthetic pathways (SBPs) of mammals and T.
cruzi.
In this paper, we discuss the major steps of the SBP in mammals, yeast and T.
cruzi, focusing on the IPC synthase and ceramide remodeling of T.
cruzi as potential therapeutic targets for Chagas disease.
American Psychological Association (APA)
Koeller, Carolina Macedo& Heise, Norton. 2011. The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease. Enzyme Research،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-488004
Modern Language Association (MLA)
Koeller, Carolina Macedo& Heise, Norton. The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease. Enzyme Research No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-488004
American Medical Association (AMA)
Koeller, Carolina Macedo& Heise, Norton. The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-488004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488004