Effect of Traditional Chinese Herbal Medicine with Antiquorum Sensing Activity on Pseudomonas aeruginosa
Joint Authors
Zhu, Wei
Zhou, Shuxin
Zhuang, Xiyi
Fu, Jiangyan
Chu, Weihua
Jiang, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Traditional Chinese herbal medicines (TCHMs) were tested for their ability of antiquorum sensing.
Water extracts of Rhubarb, Fructus gardeniae, and Andrographis paniculata show antiquorumsensing activity when using Chromobacterium violaceum CV12472 as reporter; the sub-MIC concentrations of these TCHMs were tested against AHL-dependent phenotypic expressions of PAO1.
Results showed significant reduction in pyocyanin pigment, protease, elastase production, and biofilm formation in PAO1 without inhibiting the bacterial growth, revealing that the QSI by the extracts is not related to static or killing effects on the bacteria.
The results indicate a potential modulation of bacterial cell-cell communication, P.
aeruginosa biofilm, and virulence factors by traditional Chinese herbal medicine.
This study introduces not only a new mode of action for traditional Chinese herbal medicines, but also a potential new therapeutic direction for the treatment of bacterial infections, which have QSI activity and might be important in reducing virulence and pathogenicity of pathogenic bacteria.
American Psychological Association (APA)
Chu, Weihua& Zhou, Shuxin& Jiang, Yan& Zhu, Wei& Zhuang, Xiyi& Fu, Jiangyan. 2013. Effect of Traditional Chinese Herbal Medicine with Antiquorum Sensing Activity on Pseudomonas aeruginosa. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-488016
Modern Language Association (MLA)
Chu, Weihua…[et al.]. Effect of Traditional Chinese Herbal Medicine with Antiquorum Sensing Activity on Pseudomonas aeruginosa. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-488016
American Medical Association (AMA)
Chu, Weihua& Zhou, Shuxin& Jiang, Yan& Zhu, Wei& Zhuang, Xiyi& Fu, Jiangyan. Effect of Traditional Chinese Herbal Medicine with Antiquorum Sensing Activity on Pseudomonas aeruginosa. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-488016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488016