Neurovascular Unit in Chronic Pain
Joint Authors
Fabene, Paolo Francesco
Radu, Beatrice Mihaela
Osculati, Francesco
Bramanti, Placido
Flonta, Maria-Luisa
Radu, Mihai
Bertini, Giuseppe
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-05
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Chronic pain is a debilitating condition with major socioeconomic impact, whose neurobiological basis is still not clear.
An involvement of the neurovascular unit (NVU) has been recently proposed.
In particular, the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), two NVU key players, may be affected during the development of chronic pain; in particular, transient permeabilization of the barrier is suggested by several inflammatory- and nerve-injury-based pain models, and we argue that the clarification of molecular BBB/BSCB permeabilization events will shed new light in understanding chronic pain mechanisms.
Possible biases in experiments supporting this theory and its translational potentials are discussed.
Moving beyond an exclusive focus on the role of the endothelium, we propose that our understanding of the mechanisms subserving chronic pain will benefit from the extension of research efforts to the NVU as a whole.
In this view, the available evidence on the interaction between analgesic drugs and the NVU is here reviewed.
Chronic pain comorbidities, such as neuroinflammatory and neurodegenerative diseases, are also discussed in view of NVU changes, together with innovative pharmacological solutions targeting NVU components in chronic pain treatment.
American Psychological Association (APA)
Radu, Beatrice Mihaela& Bramanti, Placido& Osculati, Francesco& Flonta, Maria-Luisa& Radu, Mihai& Bertini, Giuseppe…[et al.]. 2013. Neurovascular Unit in Chronic Pain. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-488017
Modern Language Association (MLA)
Radu, Beatrice Mihaela…[et al.]. Neurovascular Unit in Chronic Pain. Mediators of Inflammation No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-488017
American Medical Association (AMA)
Radu, Beatrice Mihaela& Bramanti, Placido& Osculati, Francesco& Flonta, Maria-Luisa& Radu, Mihai& Bertini, Giuseppe…[et al.]. Neurovascular Unit in Chronic Pain. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-488017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488017