![](/images/graphics-bg.png)
Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia
Joint Authors
Oguma, Keiji
Suzuki, Tomonori
Yokoyama, Teruhiko
Watanabe, Toshihiro
Ohyama, Tohru
Yamamoto, Yumiko
Matsuka, Yoshizo
Nishikawa, Atsushi
Dwi Fatmawati, Ni Nengah
Nagai, Atsushi
Kuboki, Takuo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Type A neurotoxin (NTX) of Clostridium botulinum was purified by a simple procedure using a lactose gel column.
The toxicity of this purified toxin preparation was retained for at least 1 year at −30°C by supplementation with either 0.1% albumin or 0.05% albumin plus 1% trehalose.
When purified NTX was used to treat 49 patients with urinary incontinence caused by either refractory idiopathic or neurogenic detrusor overactivity, 36 patients showed significant improvement in symptoms.
These beneficial effects were also observed in cases of prostatic hyperplasia.
The results obtained with NTX were similar to that of Botox.
The effects of NTX on trigeminal neuralgia induced by infraorbital nerve constriction (IoNC) in rats were also studied.
Trigeminal ganglion neurons from ipsilateral to IoNC exhibited significantly faster onset of FM4-64 release than sham-operated contralateral neurons.
Intradermal injection of NTX in the area of IoNC alleviated IoNC-induced pain behavior and reduced the exaggerated FM4-64 release in trigeminal ganglion neurons.
American Psychological Association (APA)
Matsuka, Yoshizo& Yokoyama, Teruhiko& Yamamoto, Yumiko& Suzuki, Tomonori& Dwi Fatmawati, Ni Nengah& Nishikawa, Atsushi…[et al.]. 2012. Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-488021
Modern Language Association (MLA)
Matsuka, Yoshizo…[et al.]. Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia. Journal of Toxicology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-488021
American Medical Association (AMA)
Matsuka, Yoshizo& Yokoyama, Teruhiko& Yamamoto, Yumiko& Suzuki, Tomonori& Dwi Fatmawati, Ni Nengah& Nishikawa, Atsushi…[et al.]. Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-488021
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488021