The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes
Joint Authors
Zhang, Li
Wang, Aiyuan
Huang, Jingxiang
Guo, Weimin
Chen, Jifeng
Yuan, Mei
Zhao, Bin
Peng, Jiang
Lu, Shibi
Liu, Shuyun
Wang, Yu
Xu, Wenjing
Guo, Quanyi
Gao, Yue
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS).
Articular cartilage ECM plays a crucial role in regulating chondrocyte metabolism and functions, such as organized cytoskeleton through integrin-mediated signaling via cell-matrix interaction.
Cell signaling through integrins regulates several chondrocyte functions, including differentiation, metabolism, matrix remodeling, responses to mechanical stimulation, and cell survival.
The major signaling pathways that regulate chondrogenesis have been identified as wnt signal, nitric oxide (NO) signal, protein kinase C (PKC), and retinoic acid (RA) signal.
Integrins are a large family of molecules that are central regulators in multicellular biology.
They orchestrate cell-cell and cell-matrix adhesive interactions from embryonic development to mature tissue function.
In this review, we emphasize the signaling molecule effect and the biomechanics effect of cartilage ECM on chondrogenesis.
American Psychological Association (APA)
Gao, Yue& Liu, Shuyun& Huang, Jingxiang& Guo, Weimin& Chen, Jifeng& Zhang, Li…[et al.]. 2014. The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-488032
Modern Language Association (MLA)
Gao, Yue…[et al.]. The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-488032
American Medical Association (AMA)
Gao, Yue& Liu, Shuyun& Huang, Jingxiang& Guo, Weimin& Chen, Jifeng& Zhang, Li…[et al.]. The ECM-Cell Interaction of Cartilage Extracellular Matrix on Chondrocytes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-488032
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488032