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Proteomic Profiling of the Dystrophin-Deficient MDX Heart Reveals Drastically Altered Levels of Key Metabolic and Contractile Proteins
Joint Authors
Ohlendieck, Kay
Jockusch, Harald
Lewis, Caroline
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-23
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Although Duchenne muscular dystrophy is primarily classified as a neuromuscular disease, cardiac complications play an important role in the course of this X-linked inherited disorder.
The pathobiochemical steps causing a progressive decline in the dystrophic heart are not well understood.
We therefore carried out a fluorescence difference in-gel electrophoretic analysis of 9-month-old dystrophin-deficient versus age-matched normal heart, using the established MDX mouse model of muscular dystrophy-related cardiomyopathy.
Out of 2,509 detectable protein spots, 79 2D-spots showed a drastic differential expression pattern, with the concentration of 3 proteins being increased, including nucleoside diphosphate kinase and lamin-A/C, and of 26 protein species being decreased, including ATP synthase, fatty acid binding-protein, isocitrate dehydrogenase, NADH dehydrogenase, porin, peroxiredoxin, adenylate kinase, tropomyosin, actin, and myosin light chains.
Hence, the lack of cardiac dystrophin appears to trigger a generally perturbed protein expression pattern in the MDX heart, affecting especially energy metabolism and contractile proteins.
American Psychological Association (APA)
Lewis, Caroline& Jockusch, Harald& Ohlendieck, Kay. 2010. Proteomic Profiling of the Dystrophin-Deficient MDX Heart Reveals Drastically Altered Levels of Key Metabolic and Contractile Proteins. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-20.
https://search.emarefa.net/detail/BIM-488038
Modern Language Association (MLA)
Lewis, Caroline…[et al.]. Proteomic Profiling of the Dystrophin-Deficient MDX Heart Reveals Drastically Altered Levels of Key Metabolic and Contractile Proteins. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-20.
https://search.emarefa.net/detail/BIM-488038
American Medical Association (AMA)
Lewis, Caroline& Jockusch, Harald& Ohlendieck, Kay. Proteomic Profiling of the Dystrophin-Deficient MDX Heart Reveals Drastically Altered Levels of Key Metabolic and Contractile Proteins. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-20.
https://search.emarefa.net/detail/BIM-488038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488038