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Immunopathological Aspects of Experimental Trypanosoma cruzi Reinfections
Joint Authors
da Silva, Crislaine Aparecida
Rodrigues, Virmondes
Castellano, Lúcio Roberto
Vinícius da Silva, Marcos
Borges, Diego Costa
Reis, Marlene Antônia dos
Ramirez, Luis Eduardo
Rodrigues, Denise Bertulucci Rocha
Machado, Juliana Reis
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chagas disease is caused by Trypanosoma cruzi infection.
Besides the host-related factors, such as immune response and genetic background, the parasite, strain, and occurrences of reinfection episodes, may influence disease outcome.
Our results demonstrate that both the primary infection and the reinfection with the Colombiana strain are connected with lower survival rate of the mice.
After reinfection, parasitaemia is approximately ten times lower than in primary infected animals.
Only Colombiana, Colombiana/Colombiana, and Y/Colombiana groups presented amastigote nests in cardiac tissue.
Moreover, the mice infected and/or reinfected with the Colombiana strain had more T.
cruzi nests, more intense inflammatory infiltrate, and higher in situ expression of TNF-α and IFN-γ than Y strain.
Antigen-stimulated spleen cells from infected and/or reinfected animals produced higher levels of TNF-α, IFN-γ, and IL-10.
Our results reinforce the idea that Chagas disease outcome is influenced by the strain of the infective parasite, being differentially modulated during reinfection episodes.
It highlights the need of control strategies involving parasite strain characterization in endemic areas for Chagas disease.
American Psychological Association (APA)
Machado, Juliana Reis& Vinícius da Silva, Marcos& Borges, Diego Costa& da Silva, Crislaine Aparecida& Ramirez, Luis Eduardo& Reis, Marlene Antônia dos…[et al.]. 2014. Immunopathological Aspects of Experimental Trypanosoma cruzi Reinfections. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-488060
Modern Language Association (MLA)
Machado, Juliana Reis…[et al.]. Immunopathological Aspects of Experimental Trypanosoma cruzi Reinfections. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-488060
American Medical Association (AMA)
Machado, Juliana Reis& Vinícius da Silva, Marcos& Borges, Diego Costa& da Silva, Crislaine Aparecida& Ramirez, Luis Eduardo& Reis, Marlene Antônia dos…[et al.]. Immunopathological Aspects of Experimental Trypanosoma cruzi Reinfections. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-488060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488060