![](/images/graphics-bg.png)
Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance
Author
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Resistance to the HER2-targeted antibody trastuzumab is a major clinical concern in the treatment of HER2-overexpressing metastatic breast cancer.
Increased expression or signaling of the insulin-like growth factor-I receptor (IGF-IR) has been reported in a subset of cell lines and clinical samples derived from trastuzumab-resistant breast cancers.
Genetic and pharmacologic inhibition of IGF-IR signaling has been shown to improve response to trastuzumab in trastuzumab-naïve and trastuzumab-resistant models.
In this paper, we will discuss the role of IGF-IR signaling in trastuzumab resistance.
Further, we will discuss cotargeting IGF-IR and HER2 as a potential therapeutic strategy for HER2-over-expressing breast cancers that have progressed on trastuzumab treatment.
American Psychological Association (APA)
Nahta, Rita. 2012. Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-488076
Modern Language Association (MLA)
Nahta, Rita. Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance. Chemotherapy Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-488076
American Medical Association (AMA)
Nahta, Rita. Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-488076
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488076