Resistant Thyrotoxicosis in a Patient with Graves Disease : A Case Report

Joint Authors

Masood, Qamar
Saleem, Taimur
Sheikh, Aisha

Source

Journal of Thyroid Research

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-08-10

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Biology
Diseases
Medicine

Abstract EN

Background.

Conventional management of thyrotoxicosis includes antithyroid drugs, radioactive iodine, and surgery while adjunctive treatment includes beta-blockers, corticosteroids, inorganic iodide and iopanoic acid.

Very rarely, patients may be resistant to these modalities and require additional management.

Case Presentation.

A 50-year-old lady presented with weight loss and palpitations diagnosed as atrial fibrillation.

Her past history was significant for right thyroid lobectomy for thyrotoxicosis.

Thyroid functions tests at this presentation showed free T4 of 6.63 ng/dl (normal range: 0.93–1.7) and TSH of <0.005 μIU/mL (normal range: 0.4–4.0).

She was given aspirin, propranolol, heparin and carbimazole; however free T4 failed to normalize.

Switching to propylthiouracil (PTU) did not prove successful.

She was then given high doses of prednisolone (1 mg/kg/day) and lithium (400 mg twice daily) which prepared the patient for radioactive iodine treatment by reducing free T4 levels (2.82 ng/dl).

Two doses of radioactive iodine were then administered 6 months apart.

Subsequently she became hypothyroid and was started on thyroid replacement therapy.

Conclusion.

This case highlights management options in patients with resistant thyrotoxicosis.

Radioactive iodine and surgery are definitive modes of treatment in such complex cases while steroids and lithium play an important role in preparing patients for more definitive treatment.

American Psychological Association (APA)

Saleem, Taimur& Sheikh, Aisha& Masood, Qamar. 2011. Resistant Thyrotoxicosis in a Patient with Graves Disease : A Case Report. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-488086

Modern Language Association (MLA)

Saleem, Taimur…[et al.]. Resistant Thyrotoxicosis in a Patient with Graves Disease : A Case Report. Journal of Thyroid Research No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-488086

American Medical Association (AMA)

Saleem, Taimur& Sheikh, Aisha& Masood, Qamar. Resistant Thyrotoxicosis in a Patient with Graves Disease : A Case Report. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-488086

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-488086