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The Role of the PGC1α Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy
Joint Authors
Brunzell, John D.
Deeb, Samir S.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The Diabetes Control and Complications Trial (DCCT) involved intensive diabetes therapy of subjects with type 1 diabetes mellitus (T1DM) for an average period of 6.5 years.
A subset of these subjects gained excessive weight.
We tested for association of polymorphisms in 8 candidate genes with the above trait.
We found the Gly482Ser polymorphism in the peroxisome proliferator-activated receptor γ coactivator-1α (PGC1α) to be significantly associated with weight gain in males (P=.0045) but not in females.
The Ser allele was associated with greater weight gain than the Gly allele (P=.005).
Subjects with a family history of type 2 diabetes mellitus (T2DM) were more common among those who gained excessive weight.
We conclude that T2DM and the Gly482Ser polymorphism in PGC1α contribute to the effect of intensive diabetes therapy on weight gain in males with T1DM.
American Psychological Association (APA)
Deeb, Samir S.& Brunzell, John D.. 2009. The Role of the PGC1α Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy. PPAR Research،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-488115
Modern Language Association (MLA)
Deeb, Samir S.& Brunzell, John D.. The Role of the PGC1α Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy. PPAR Research No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-488115
American Medical Association (AMA)
Deeb, Samir S.& Brunzell, John D.. The Role of the PGC1α Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-488115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488115