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PBC : Animal Models of Cholangiopathies and Possible Endogenous Viral Infections
Joint Authors
Ninomiya, Masashi
Shimosegawa, Tooru
Ueno, Yoshiyuki
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Primary Biliary Cirrhosis (PBC) is considered an autoimmune disease characterized by immune-mediated destruction of the intrahepatic bile ducts and its characteristic serologic marker, the anti-mitochondrial antibody (AMA).
Several factors were proposed to clarify the pathological and immunological mechanisms of PBC.
Immunological reaction with a bacterial or a viral association was identified in the previous report, and it seems probable that PBC was thought to have such an etiology.
The majority of patients with PBC was reported to have both RT-PCR and immunohistochemistry evidence of human betaretrovirus infection in lymph nodes or in 2008, the patient who developed PBC with high HIV viral load had an antiviral therapy and recovered.
To understand the etiology of PBC associated with infection, several factors should be considered and especially animal models may be useful.
In this paper, we introduce three typical animal models of PBC: the dominant-negative form of transforming growth factor-β receptor type II (dnTGFβRII) mouse, IL-2Rα−/− mouse and NOD.c3c4 mouse, are enumerated and described, and we discuss previous reports of viral infection associated with PBC and consider the etiology of PBC from our analysis of results in NOD.c3c4 mouse.
American Psychological Association (APA)
Ninomiya, Masashi& Ueno, Yoshiyuki& Shimosegawa, Tooru. 2011. PBC : Animal Models of Cholangiopathies and Possible Endogenous Viral Infections. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488116
Modern Language Association (MLA)
Ninomiya, Masashi…[et al.]. PBC : Animal Models of Cholangiopathies and Possible Endogenous Viral Infections. International Journal of Hepatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-488116
American Medical Association (AMA)
Ninomiya, Masashi& Ueno, Yoshiyuki& Shimosegawa, Tooru. PBC : Animal Models of Cholangiopathies and Possible Endogenous Viral Infections. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488116
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488116