Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-18
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
A dysfunction of cortical and limbic GABAergic circuits has been postulated to contribute to multiple neurodevelopmental disorders in humans, including schizophrenia, autism, and epilepsy.
In the current paper, I summarize the characteristics that underlie the great diversity of cortical GABAergic interneurons and explore how the multiple roles of these cells in developing and mature circuits might contribute to the aforementioned disorders.
Furthermore, I review the tightly controlled genetic cascades that determine the fate of cortical interneurons and summarize how the dysfunction of genes important for the generation, specification, maturation, and function of cortical interneurons might contribute to these disorders.
American Psychological Association (APA)
Rossignol, E.. 2011. Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders. Neural Plasticity،Vol. 2011, no. 2011, pp.1-25.
https://search.emarefa.net/detail/BIM-488120
Modern Language Association (MLA)
Rossignol, E.. Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders. Neural Plasticity No. 2011 (2011), pp.1-25.
https://search.emarefa.net/detail/BIM-488120
American Medical Association (AMA)
Rossignol, E.. Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders. Neural Plasticity. 2011. Vol. 2011, no. 2011, pp.1-25.
https://search.emarefa.net/detail/BIM-488120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488120