Analyzing Microarray Data of Alzheimer's Using Cluster Analysis to Identify the Biomarker Genes
Joint Authors
Allam, Apparao
Guttula, Satya vani
Gumpeny, R. Sridhar
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Alzheimer is characterized by the presence of senile plaques and neurofibrillary tangles in cortical regions of the brain.
The experimental data is taken from Gene Expression Omnibus.
A hierarchical Cluster analysis and TreeView were performed to group genes on the basis of the expression pattern.
The dynamic change of expression over time and diverse patterns of expression support the concept of a complex local milieu.
TreeView allows the organized data to be visualized.
List of 24 genes were obtained which showed high expression levels.
Three genes, SORL1, APP, and APOE, are suspected to cause Alzheimer’s whereas the other 21 genes are related to other diseases but may also be found to be associated with Alzheimer’s, and these are TMEM59, CCT4, IGF2R, SFPQ, PRDX3, RNF14, IDS, SSBP1, SYNE2, TXNL4A, STXBP3, SMARCB1, ULK2, AGTPBP1, FABP7, CALB1, H2AFY, COPA, SAP18, ATIC and SYNCRIP.
American Psychological Association (APA)
Guttula, Satya vani& Allam, Apparao& Gumpeny, R. Sridhar. 2012. Analyzing Microarray Data of Alzheimer's Using Cluster Analysis to Identify the Biomarker Genes. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-488132
Modern Language Association (MLA)
Guttula, Satya vani…[et al.]. Analyzing Microarray Data of Alzheimer's Using Cluster Analysis to Identify the Biomarker Genes. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-488132
American Medical Association (AMA)
Guttula, Satya vani& Allam, Apparao& Gumpeny, R. Sridhar. Analyzing Microarray Data of Alzheimer's Using Cluster Analysis to Identify the Biomarker Genes. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-488132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488132