Oxidized Extracellular DNA as a Stress Signal in Human Cells
Joint Authors
Ermakov, Aleksei V.
Izevskaya, Vera L.
Baranova, Ancha
Konkova, Marina S.
Kostyuk, Svetlana V.
Veiko, Natalya N.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The term “cell-free DNA” (cfDNA) was recently coined for DNA fragments from plasma/serum, while DNA present in in vitro cell culture media is known as extracellular DNA (ecDNA).
Under oxidative stress conditions, the levels of oxidative modification of cellular DNA and the rate of cell death increase.
Dying cells release their damaged DNA, thus, contributing oxidized DNA fragments to the pool of cfDNA/ecDNA.
Oxidized cell-free DNA could serve as a stress signal that promotes irradiation-induced bystander effect.
Evidence points to TLR9 as a possible candidate for oxidized DNA sensor.
An exposure to oxidized ecDNA stimulates a synthesis of reactive oxygen species (ROS) that evokes an adaptive response that includes transposition of the homologous loci within the nucleus, polymerization and the formation of the stress fibers of the actin, as well as activation of the ribosomal gene expression, and nuclear translocation of NF-E2 related factor-2 (NRF2) that, in turn, mediates induction of phase II detoxifying and antioxidant enzymes.
In conclusion, the oxidized DNA is a stress signal released in response to oxidative stress in the cultured cells and, possibly, in the human body; in particular, it might contribute to systemic abscopal effects of localized irradiation treatments.
American Psychological Association (APA)
Ermakov, Aleksei V.& Konkova, Marina S.& Kostyuk, Svetlana V.& Izevskaya, Vera L.& Baranova, Ancha& Veiko, Natalya N.. 2013. Oxidized Extracellular DNA as a Stress Signal in Human Cells. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-488174
Modern Language Association (MLA)
Ermakov, Aleksei V.…[et al.]. Oxidized Extracellular DNA as a Stress Signal in Human Cells. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-488174
American Medical Association (AMA)
Ermakov, Aleksei V.& Konkova, Marina S.& Kostyuk, Svetlana V.& Izevskaya, Vera L.& Baranova, Ancha& Veiko, Natalya N.. Oxidized Extracellular DNA as a Stress Signal in Human Cells. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-488174
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488174