Rosiglitazone Suppresses the Growth and Invasiveness of SGC-7901 Gastric Cancer Cells and Angiogenesis In Vitro via PPARγ Dependent and Independent Mechanisms
Joint Authors
Song, Xin
Chen, Minhu
Hu, Pinjin
Chen, Jie
He, Qing
Pang, Ruiping
Chen, Huixin
Chen, Baili
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Although thiazolidinediones (TZDs) were found to be ligands for peroxisome proliferators-activated receptorγ (PPARγ), the mechanism by which TZDs exert their anticancer effect remains unclear.
Furthermore, the effect of TZDs on metastatic and angiogenesis potential of cancer cells is unknown.
Our results in this paper show that rosiglitazone inhibited SGC-7901 gastric cancer cells growth, caused G1 cell cycle arrest and induced apoptosis in a dose-dependent manner.
The effects of rosiglitazone on SGC-7901 cancer cells were completely reversed by treatment with PPARγ antagonist GW9662.
Rosiglitazone inhibited SGC-7901 cell migration, invasiveness, and the expression of MMP-2 in dose-dependent manner via PPARγ-independent manner.
Rosiglitazone reduced the VEGF induced angiogenesis of HUVEC in dose-dependent manner through PPARγ-dependent pathway.
Moreover, rosiglitazone did not affect the expression of VEGF by SGC-7901 cells.
Our results demonstrated that by PPARγ ligand, rosiglitazone inhibited growth and invasiveness of SGC-7901 gastric cancer cells and angiogenesis in vitro via PPARγ-dependent or -independent pathway.
American Psychological Association (APA)
He, Qing& Pang, Ruiping& Song, Xin& Chen, Jie& Chen, Huixin& Chen, Baili…[et al.]. 2008. Rosiglitazone Suppresses the Growth and Invasiveness of SGC-7901 Gastric Cancer Cells and Angiogenesis In Vitro via PPARγ Dependent and Independent Mechanisms. PPAR Research،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-488179
Modern Language Association (MLA)
He, Qing…[et al.]. Rosiglitazone Suppresses the Growth and Invasiveness of SGC-7901 Gastric Cancer Cells and Angiogenesis In Vitro via PPARγ Dependent and Independent Mechanisms. PPAR Research No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-488179
American Medical Association (AMA)
He, Qing& Pang, Ruiping& Song, Xin& Chen, Jie& Chen, Huixin& Chen, Baili…[et al.]. Rosiglitazone Suppresses the Growth and Invasiveness of SGC-7901 Gastric Cancer Cells and Angiogenesis In Vitro via PPARγ Dependent and Independent Mechanisms. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-488179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488179
