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Leptin Deficiency and Its Effects on Tibial and Vertebral Bone Mechanical Properties in Mature Genetically Lean and Obese JCR : LA-Corpulent Rats
Joint Authors
Zernicke, Ronald F.
LaMothe, Jeremy M.
Reimer, Raylene A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Leptin signaling deficient rodents have emerged as models of obesity/insulin resistance syndrome.
Altered leptin signaling, however, can affect axial and appendicular bone geometrical properties differently, and, thus, we hypothesized that leptin-deficiency would differentially influence mechanical properties of vertebrae and tibiae compared to lean rats.
Mature (9 mo) leptin receptor deficient obese (cp/cp; n=8) and lean (+/?; n=7) male JCR:LA-corpulent rats were used to test that hypothesis.
Tibiae and the sixth lumbar vertebrae (L6) were scanned with micro-CT and were broken in three point-bending (tibiae) or axial loading (L6).
Supporting the hypothesis, vertebrae and tibiae were differentially affected by leptin signaling deficiency.
Tibiae, but not vertebrae, were significantly shorter in obese rats and achieved a significantly greater load (>18%), displacement (>15%), and stress (>18%) at the proportional limit, relative to the lean rats.
Conversely, L6 in obese rats had significantly reduced displacement (>25%) and strain (>32%) at proportional limit, relative to the lean rats.
Those combined results suggest that the etiology and duration of obesity may be important determinants of bone mechanical properties, and axial and appendicular bones may be affected differently.
American Psychological Association (APA)
Reimer, Raylene A.& LaMothe, Jeremy M.& Zernicke, Ronald F.. 2012. Leptin Deficiency and Its Effects on Tibial and Vertebral Bone Mechanical Properties in Mature Genetically Lean and Obese JCR : LA-Corpulent Rats. Journal of Obesity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-488195
Modern Language Association (MLA)
Reimer, Raylene A.…[et al.]. Leptin Deficiency and Its Effects on Tibial and Vertebral Bone Mechanical Properties in Mature Genetically Lean and Obese JCR : LA-Corpulent Rats. Journal of Obesity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-488195
American Medical Association (AMA)
Reimer, Raylene A.& LaMothe, Jeremy M.& Zernicke, Ronald F.. Leptin Deficiency and Its Effects on Tibial and Vertebral Bone Mechanical Properties in Mature Genetically Lean and Obese JCR : LA-Corpulent Rats. Journal of Obesity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-488195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488195