MicroRNAs in Head and Neck Cancer
Joint Authors
Wu, Jennifer
John, Keziah
Farah, Camile S.
Lee, Bing-Wei
Source
International Journal of Dentistry
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
microRNAs (miRs) are small noncoding single-stranded RNAs, about 19–25 nucleotides long.
They have been shown to be capable of altering mRNA expression; thus some are oncogenic or tumour suppressive in nature and are regulated by cellular and epigenetic factors.
The molecular pathogenic pathway of many cancers has been modified since the discovery of miRs.
Head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer in the world, has recently been associated with infection by the human papillomavirus (HPV).
miR expression profiles are altered in the transition from dysplasia to carcinoma, with some changes being specific to the underlying risk factor.
This difference is particularly significant in HPV-positive HNSCC where host miRs are modulated by the virus, creating a different profile to HPV-negative HNSCC.
Saliva, as an easily collected proximal biofluid containing numerous miRs, presents an attractive noninvasive diagnostic tool in detecting HNSCC and determining prognosis.
Furthermore, miRs may play a role in the analysis of surgical margins for residual tumour extension and in the development of novel miR-based therapeutic targets and agents.
American Psychological Association (APA)
John, Keziah& Wu, Jennifer& Lee, Bing-Wei& Farah, Camile S.. 2013. MicroRNAs in Head and Neck Cancer. International Journal of Dentistry،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-488201
Modern Language Association (MLA)
John, Keziah…[et al.]. MicroRNAs in Head and Neck Cancer. International Journal of Dentistry No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-488201
American Medical Association (AMA)
John, Keziah& Wu, Jennifer& Lee, Bing-Wei& Farah, Camile S.. MicroRNAs in Head and Neck Cancer. International Journal of Dentistry. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-488201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488201