Basal Cell Carcinoma : From the Molecular Understanding of the Pathogenesis to Targeted Therapy of Progressive Disease
Joint Authors
Göppner, Daniela
Leverkus, Martin
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Due to intensified research over the past decade, the Hedgehog (HH) pathway has been identified as a pivotal defect implicated in roughly 25% of all cancers.
As one of the most frequent cancer worldwide, the development of Basal cell carcinoma (BCC) due to activation of the HH pathway has been convincingly demonstrated.
Thus the discovery of this central tumor-promoting signalling pathway has not only revolutionized the understanding of BCC carcinogenesis but has also enabled the development of a completely novel therapeutic approach.
Targeting just a few of several potential mutations, HH inhibitors such as GDC-0449 achieved already the first promising results in metastatic or locally advanced BCC.
This paper summarizes the current understanding of BCC carcinogenesis and describes the current “mechanism-based” therapeutic strategies.
American Psychological Association (APA)
Göppner, Daniela& Leverkus, Martin. 2010. Basal Cell Carcinoma : From the Molecular Understanding of the Pathogenesis to Targeted Therapy of Progressive Disease. Journal of Skin Cancer،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-488205
Modern Language Association (MLA)
Göppner, Daniela& Leverkus, Martin. Basal Cell Carcinoma : From the Molecular Understanding of the Pathogenesis to Targeted Therapy of Progressive Disease. Journal of Skin Cancer No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-488205
American Medical Association (AMA)
Göppner, Daniela& Leverkus, Martin. Basal Cell Carcinoma : From the Molecular Understanding of the Pathogenesis to Targeted Therapy of Progressive Disease. Journal of Skin Cancer. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-488205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488205