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Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model
Joint Authors
Reinebrant, Hanna E.
Buller, Kathryn M.
Wixey, Julie A.
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Identifying which specific neuronal phenotypes are vulnerable to neonatal hypoxia-ischemia, where in the brain they are damaged, and the mechanisms that produce neuronal losses are critical to determine the anatomical substrates responsible for neurological impairments in hypoxic-ischemic brain-injured neonates.
Here we describe our current work investigating how the serotonergic network in the brain is disrupted in a rodent model of preterm hypoxia-ischemia.
One week after postnatal day 3 hypoxia-ischemia, losses of serotonergic raphé neurons, reductions in serotonin levels in the brain, and reduced serotonin transporter expression are evident.
These changes can be prevented using two anti-inflammatory interventions; the postinsult administration of minocycline or ibuprofen.
However, each drug has its own limitations and benefits for use in neonates to stem damage to the serotonergic network after hypoxia-ischemia.
By understanding the fundamental mechanisms underpinning hypoxia-ischemia-induced serotonergic damage we will hopefully move closer to developing a successful clinical intervention to treat neonatal brain injury.
American Psychological Association (APA)
Buller, Kathryn M.& Wixey, Julie A.& Reinebrant, Hanna E.. 2012. Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model. Neurology Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-488214
Modern Language Association (MLA)
Buller, Kathryn M.…[et al.]. Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model. Neurology Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-488214
American Medical Association (AMA)
Buller, Kathryn M.& Wixey, Julie A.& Reinebrant, Hanna E.. Disruption of the Serotonergic System after Neonatal Hypoxia-Ischemia in a Rodent Model. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-488214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488214