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Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions
Joint Authors
Grijalvo, Santiago
Janoušek, Jiří
Bělohradský, Martin
Starý, Ivo
Eritja, Ramon
Somoza, Alvaro
Pérez-Rentero, Sónia
Stará, Irena G.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Oligonucleotide conjugates carrying a single functionalized tetrathiafulvalene (TTF) unit linked through a threoninol molecule to the 3′ or 5′ ends were synthesized together with their complementary oligonucleotides carrying a TTF, pyrene, or pentafluorophenyl group.
TTF-oligonucleotide conjugates formed duplexes with higher thermal stability than the corresponding unmodified oligonucleotides and pyrene- and pentafluorophenyl-modified oligonucleotides.
TTF-modified oligonucleotides are able to bind to citrate-stabilized gold nanoparticles (AuNPs) and produce stable gold AuNPs functionalized with oligonucleotides.
Finally, TTF-oligoribonucleotides have been synthesized to produce siRNA duplexes carrying TTF units.
The presence of the TTF molecule is compatible with the RNA interference mechanism for gene inhibition.
American Psychological Association (APA)
Pérez-Rentero, Sónia& Somoza, Alvaro& Grijalvo, Santiago& Janoušek, Jiří& Bělohradský, Martin& Stará, Irena G.…[et al.]. 2013. Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-488237
Modern Language Association (MLA)
Pérez-Rentero, Sónia…[et al.]. Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions. Journal of Chemistry No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-488237
American Medical Association (AMA)
Pérez-Rentero, Sónia& Somoza, Alvaro& Grijalvo, Santiago& Janoušek, Jiří& Bělohradský, Martin& Stará, Irena G.…[et al.]. Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-488237
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488237