Measurements in the Blood of BDNF for RA Patients and in Response to Anti-TNF Treatment Help Us to Clarify the Magnitude of Centrally Related Pain and to Explain the Relief of This Pain upon Treatment

Joint Authors

Dalén, Tore
Rantapää-Dahlqvist, Solbritt
Forsgren, Sture
Grimsholm, Ola

Source

International Journal of Inflammation

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-06-08

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases
Medicine

Abstract EN

Brain-derived neurotrophic factor (BDNF) is a neurotrophin with functions related to neuronal survival/proliferation processes and inflammation.

BDNF is also an important central pain mediator.

The levels of BDNF have been found to be high for RA patients with severe disease and to become lowered in response to anti-TNF treatment.

New information says that the levels of BDNF in the blood parallel the BDNF concentrations in the brain and that BDNF can pass the blood-brain barrier.

Furthermore, most of the circulating BDNF is produced in the brain.

Habitual and regular exercise, in contrast to temporary exercise, does also lead to a lowering of BDNF blood levels.

Both anti-TNF treatment and habitual and regular exercise do have pain-relieving effects.

It might be that the pain-relieving effect of anti-TNF treatment is related to an affection of central neuronal regions, hereby influencing BDNF production.

Measurements of BDNF in the blood help us to clarify the magnitude of centrally related pain for RA patients and help us to explain the relief of this pain in response to anti-TNF treatment.

American Psychological Association (APA)

Forsgren, Sture& Grimsholm, Ola& Dalén, Tore& Rantapää-Dahlqvist, Solbritt. 2011. Measurements in the Blood of BDNF for RA Patients and in Response to Anti-TNF Treatment Help Us to Clarify the Magnitude of Centrally Related Pain and to Explain the Relief of This Pain upon Treatment. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-488240

Modern Language Association (MLA)

Forsgren, Sture…[et al.]. Measurements in the Blood of BDNF for RA Patients and in Response to Anti-TNF Treatment Help Us to Clarify the Magnitude of Centrally Related Pain and to Explain the Relief of This Pain upon Treatment. International Journal of Inflammation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-488240

American Medical Association (AMA)

Forsgren, Sture& Grimsholm, Ola& Dalén, Tore& Rantapää-Dahlqvist, Solbritt. Measurements in the Blood of BDNF for RA Patients and in Response to Anti-TNF Treatment Help Us to Clarify the Magnitude of Centrally Related Pain and to Explain the Relief of This Pain upon Treatment. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-488240

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-488240