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Measurements in the Blood of BDNF for RA Patients and in Response to Anti-TNF Treatment Help Us to Clarify the Magnitude of Centrally Related Pain and to Explain the Relief of This Pain upon Treatment
Joint Authors
Dalén, Tore
Rantapää-Dahlqvist, Solbritt
Forsgren, Sture
Grimsholm, Ola
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Brain-derived neurotrophic factor (BDNF) is a neurotrophin with functions related to neuronal survival/proliferation processes and inflammation.
BDNF is also an important central pain mediator.
The levels of BDNF have been found to be high for RA patients with severe disease and to become lowered in response to anti-TNF treatment.
New information says that the levels of BDNF in the blood parallel the BDNF concentrations in the brain and that BDNF can pass the blood-brain barrier.
Furthermore, most of the circulating BDNF is produced in the brain.
Habitual and regular exercise, in contrast to temporary exercise, does also lead to a lowering of BDNF blood levels.
Both anti-TNF treatment and habitual and regular exercise do have pain-relieving effects.
It might be that the pain-relieving effect of anti-TNF treatment is related to an affection of central neuronal regions, hereby influencing BDNF production.
Measurements of BDNF in the blood help us to clarify the magnitude of centrally related pain for RA patients and help us to explain the relief of this pain in response to anti-TNF treatment.
American Psychological Association (APA)
Forsgren, Sture& Grimsholm, Ola& Dalén, Tore& Rantapää-Dahlqvist, Solbritt. 2011. Measurements in the Blood of BDNF for RA Patients and in Response to Anti-TNF Treatment Help Us to Clarify the Magnitude of Centrally Related Pain and to Explain the Relief of This Pain upon Treatment. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-488240
Modern Language Association (MLA)
Forsgren, Sture…[et al.]. Measurements in the Blood of BDNF for RA Patients and in Response to Anti-TNF Treatment Help Us to Clarify the Magnitude of Centrally Related Pain and to Explain the Relief of This Pain upon Treatment. International Journal of Inflammation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-488240
American Medical Association (AMA)
Forsgren, Sture& Grimsholm, Ola& Dalén, Tore& Rantapää-Dahlqvist, Solbritt. Measurements in the Blood of BDNF for RA Patients and in Response to Anti-TNF Treatment Help Us to Clarify the Magnitude of Centrally Related Pain and to Explain the Relief of This Pain upon Treatment. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-488240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488240