![](/images/graphics-bg.png)
Adenosine and Immune Imbalance in Visceral Leishmaniasis : The Possible Role of Ectonucleotidases
Joint Authors
Meyer-Fernandes, José Roberto
Paletta-Silva, Rafael
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Visceral leishmaniasis (VL) is the most severe form of leishmaniasis and is responsible for most Leishmania-associated deaths.
VL represents a serious public health problem that affects many countries.
The immune response in leishmaniasis is very complex and is poorly understood.
The Th1 versus Th2 paradigm does not appear to be so clear in visceral leishmaniasis, suggesting that other immunosuppressive or immune-evasion mechanisms contribute to the pathogenesis of VL.
It has been demonstrated that generation of adenosine, a potent endogenous immunosuppressant, by extracellular enzymes capable to hydrolyze adenosine tri-nucleotide (ATP) at the site of infection, can lead to immune impairment and contribute to leishmaniasis progression.
In this regard, this paper discusses the unique features in VL immunopathogenesis, including a possible role for ectonucleotidases in leishmaniasis.
American Psychological Association (APA)
Paletta-Silva, Rafael& Meyer-Fernandes, José Roberto. 2011. Adenosine and Immune Imbalance in Visceral Leishmaniasis : The Possible Role of Ectonucleotidases. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488262
Modern Language Association (MLA)
Paletta-Silva, Rafael& Meyer-Fernandes, José Roberto. Adenosine and Immune Imbalance in Visceral Leishmaniasis : The Possible Role of Ectonucleotidases. Journal of Tropical Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-488262
American Medical Association (AMA)
Paletta-Silva, Rafael& Meyer-Fernandes, José Roberto. Adenosine and Immune Imbalance in Visceral Leishmaniasis : The Possible Role of Ectonucleotidases. Journal of Tropical Medicine. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488262