Clinical and Imaging Resolution of Neonatal Hemochromatosis following Treatment
Joint Authors
Konen, Osnat
Sirota, Lea
Machtei, Ayelet
Shapiro, Rivka
Klinger, Gil
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Neonatal hemochromatosis (NH) is an acute liver disease associated with both hepatic and extrahepatic iron deposition and is a leading cause of neonatal liver transplantation.
The concept that NH is an alloimmune disease has led to the emergence of a new treatment approach utilizing exchange transfusion and intravenous immunoglobulin therapy.
We present a two-day old neonate with progressive liver dysfunction who was diagnosed with NH.
Magnetic resonance imaging confirmed tissue iron overload.
Treatment with intravenous immunoglobulins and exchange transfusion led to rapid improvement in liver function.
Follow-up physical examination at the age of 8 months showed normal development and near normal liver function.
A repeat abdominal magnetic resonance scan at 8 months showed no signs of iron deposition in the liver, pancreas, or adrenal glands.
The present report provides further support for the use of exchange transfusion and immunoglobulin therapy in NH and is the first to document resolution of typical iron deposition by magnetic resonance imaging.
American Psychological Association (APA)
Machtei, Ayelet& Klinger, Gil& Shapiro, Rivka& Konen, Osnat& Sirota, Lea. 2014. Clinical and Imaging Resolution of Neonatal Hemochromatosis following Treatment. Case Reports in Critical Care،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-488266
Modern Language Association (MLA)
Machtei, Ayelet…[et al.]. Clinical and Imaging Resolution of Neonatal Hemochromatosis following Treatment. Case Reports in Critical Care No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-488266
American Medical Association (AMA)
Machtei, Ayelet& Klinger, Gil& Shapiro, Rivka& Konen, Osnat& Sirota, Lea. Clinical and Imaging Resolution of Neonatal Hemochromatosis following Treatment. Case Reports in Critical Care. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-488266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488266