Clinical and Imaging Resolution of Neonatal Hemochromatosis following Treatment

Joint Authors

Konen, Osnat
Sirota, Lea
Machtei, Ayelet
Shapiro, Rivka
Klinger, Gil

Source

Case Reports in Critical Care

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-06-24

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Diseases

Abstract EN

Neonatal hemochromatosis (NH) is an acute liver disease associated with both hepatic and extrahepatic iron deposition and is a leading cause of neonatal liver transplantation.

The concept that NH is an alloimmune disease has led to the emergence of a new treatment approach utilizing exchange transfusion and intravenous immunoglobulin therapy.

We present a two-day old neonate with progressive liver dysfunction who was diagnosed with NH.

Magnetic resonance imaging confirmed tissue iron overload.

Treatment with intravenous immunoglobulins and exchange transfusion led to rapid improvement in liver function.

Follow-up physical examination at the age of 8 months showed normal development and near normal liver function.

A repeat abdominal magnetic resonance scan at 8 months showed no signs of iron deposition in the liver, pancreas, or adrenal glands.

The present report provides further support for the use of exchange transfusion and immunoglobulin therapy in NH and is the first to document resolution of typical iron deposition by magnetic resonance imaging.

American Psychological Association (APA)

Machtei, Ayelet& Klinger, Gil& Shapiro, Rivka& Konen, Osnat& Sirota, Lea. 2014. Clinical and Imaging Resolution of Neonatal Hemochromatosis following Treatment. Case Reports in Critical Care،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-488266

Modern Language Association (MLA)

Machtei, Ayelet…[et al.]. Clinical and Imaging Resolution of Neonatal Hemochromatosis following Treatment. Case Reports in Critical Care No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-488266

American Medical Association (AMA)

Machtei, Ayelet& Klinger, Gil& Shapiro, Rivka& Konen, Osnat& Sirota, Lea. Clinical and Imaging Resolution of Neonatal Hemochromatosis following Treatment. Case Reports in Critical Care. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-488266

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-488266