Th17 Cells in Autoimmune and Infectious Diseases
Joint Authors
García-Magallanes, Noemí
Zambrano-Zaragoza, José Francisco
Vibanco-Pérez, Norberto
Romo-Martínez, Enrique Jhonatan
Durán-Avelar, Ma. de Jesús
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically.
Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens.
Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases.
Also, they appear to be critical for controlling these disorders.
Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation.
Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23.
The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review.
American Psychological Association (APA)
Zambrano-Zaragoza, José Francisco& Romo-Martínez, Enrique Jhonatan& Durán-Avelar, Ma. de Jesús& García-Magallanes, Noemí& Vibanco-Pérez, Norberto. 2014. Th17 Cells in Autoimmune and Infectious Diseases. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-488318
Modern Language Association (MLA)
Zambrano-Zaragoza, José Francisco…[et al.]. Th17 Cells in Autoimmune and Infectious Diseases. International Journal of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-488318
American Medical Association (AMA)
Zambrano-Zaragoza, José Francisco& Romo-Martínez, Enrique Jhonatan& Durán-Avelar, Ma. de Jesús& García-Magallanes, Noemí& Vibanco-Pérez, Norberto. Th17 Cells in Autoimmune and Infectious Diseases. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-488318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488318