Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls : A Study of SNPs rs737865, rs4680, and rs165599
Joint Authors
Nikolaos, Drakoulis
Charalampos, Touloumis
Maria, Kotrotsou
Stavroula, Syriou
Vasiliki, Kalampoki
Vassilakopoulou, Dido
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Schizophrenia, a severe psychiatric condition, is characterized by disturbances of cognition, emotion, and social functioning.
The disease affects almost 1% of world population.
Recent studies evaluating the role of catechol-O-methyltransferase enzyme (COMT) polymorphisms in the pathogenesis of schizophrenia have resulted in ambiguous findings.
The current study examined the association of schizophrenia with three COMT polymorphisms, namely, rs737865, rs4680, and rs165599 in a Greek population.
There was no significant association between schizophrenia and any of the three SNPs examined.
However, haplotype analysis showed that cases have higher frequency of the T-A-A haplotype, and participants with that haplotype were at increased risk for developing schizophrenia (OR = 1.52; CL : 1.12–2.08; P=0.008).
Furthermore, patients with schizophrenia displayed an excess of TC/AA/AA and the TT/AA/GA genotypes.
Similarly a protective effect of TT/GG/GG and TT/GA/GG was suggested by our results.
American Psychological Association (APA)
Maria, Kotrotsou& Charalampos, Touloumis& Vassilakopoulou, Dido& Stavroula, Syriou& Vasiliki, Kalampoki& Nikolaos, Drakoulis. 2012. Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls : A Study of SNPs rs737865, rs4680, and rs165599. ISRN Psychiatry،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488332
Modern Language Association (MLA)
Maria, Kotrotsou…[et al.]. Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls : A Study of SNPs rs737865, rs4680, and rs165599. ISRN Psychiatry No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-488332
American Medical Association (AMA)
Maria, Kotrotsou& Charalampos, Touloumis& Vassilakopoulou, Dido& Stavroula, Syriou& Vasiliki, Kalampoki& Nikolaos, Drakoulis. Frequency Distribution of COMT Polymorphisms in Greek Patients with Schizophrenia and Controls : A Study of SNPs rs737865, rs4680, and rs165599. ISRN Psychiatry. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-488332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488332