Cyclic AMP Signaling : A Molecular Determinant of Peripheral Nerve Regeneration
Joint Authors
Assi, Mazen
Knott, Eric P.
Pearse, Damien D.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Disruption of axonal integrity during injury to the peripheral nerve system (PNS) sets into motion a cascade of responses that includes inflammation, Schwann cell mobilization, and the degeneration of the nerve fibers distal to the injury site.
Yet, the injured PNS differentiates itself from the injured central nervous system (CNS) in its remarkable capacity for self-recovery, which, depending upon the length and type of nerve injury, involves a series of molecular events in both the injured neuron and associated Schwann cells that leads to axon regeneration, remyelination repair, and functional restitution.
Herein we discuss the essential function of the second messenger, cyclic adenosine monophosphate (cyclic AMP), in the PNS repair process, highlighting the important role the conditioning lesion paradigm has played in understanding the mechanism(s) by which cyclic AMP exerts its proregenerative action.
Furthermore, we review the studies that have therapeutically targeted cyclic AMP to enhance endogenous nerve repair.
American Psychological Association (APA)
Knott, Eric P.& Assi, Mazen& Pearse, Damien D.. 2014. Cyclic AMP Signaling : A Molecular Determinant of Peripheral Nerve Regeneration. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-488335
Modern Language Association (MLA)
Knott, Eric P.…[et al.]. Cyclic AMP Signaling : A Molecular Determinant of Peripheral Nerve Regeneration. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-488335
American Medical Association (AMA)
Knott, Eric P.& Assi, Mazen& Pearse, Damien D.. Cyclic AMP Signaling : A Molecular Determinant of Peripheral Nerve Regeneration. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-488335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488335