Reticulon Protein-1C : A New Hope in the Treatment of Different Neuronal Diseases
Joint Authors
Di Sano, Federica
Piacentini, Mauro
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions.
Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy.
RTNs have been demonstrated to exert a cancer specific proapoptotic function via the interaction or the modulation of specific proteins.
Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases.
In this paper we discuss the accumulating evidence identifying RTN-1C protein as a promising target in the treatment of different pathologies such as cancer or neurodegenerative disorders.
American Psychological Association (APA)
Di Sano, Federica& Piacentini, Mauro. 2012. Reticulon Protein-1C : A New Hope in the Treatment of Different Neuronal Diseases. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-488354
Modern Language Association (MLA)
Di Sano, Federica& Piacentini, Mauro. Reticulon Protein-1C : A New Hope in the Treatment of Different Neuronal Diseases. International Journal of Cell Biology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-488354
American Medical Association (AMA)
Di Sano, Federica& Piacentini, Mauro. Reticulon Protein-1C : A New Hope in the Treatment of Different Neuronal Diseases. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-488354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488354