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Successful Use of Cyclophosphamide as an Add-On Therapy for Multiple Myeloma Patients with Acquired Resistance to Bortezomib or Lenalidomide
Joint Authors
Oyake, Tatsuo
Murai, Kazunori
Ishida, Yoji
Ito, Shigeki
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Novel agents such as thalidomide, lenalidomide, and bortezomib have been shown to possess potent activity against multiple myeloma.
However, the treatment strategy for patients who acquired resistance to these agents has not been established.
In addition to switching drug classes, intensified treatment strategy, including increase in the dosage of current agents and addition of other agents, may be considered for these patients.
We here describe 2 myeloma patients with acquired resistance to bortezomib or lenalidomide, in whom add-on therapy with low-dose cyclophosphamide was effective and tolerable.
These cases suggest that add-on therapy with cyclophosphamide is one of the treatment options to overcome resistance to novel agents in patients with multiple myeloma.
A larger prospective study is needed to clarify the efficacy and safety of this strategy for novel agent-resistant multiple myeloma.
American Psychological Association (APA)
Ito, Shigeki& Oyake, Tatsuo& Murai, Kazunori& Ishida, Yoji. 2013. Successful Use of Cyclophosphamide as an Add-On Therapy for Multiple Myeloma Patients with Acquired Resistance to Bortezomib or Lenalidomide. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-488368
Modern Language Association (MLA)
Ito, Shigeki…[et al.]. Successful Use of Cyclophosphamide as an Add-On Therapy for Multiple Myeloma Patients with Acquired Resistance to Bortezomib or Lenalidomide. Case Reports in Hematology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-488368
American Medical Association (AMA)
Ito, Shigeki& Oyake, Tatsuo& Murai, Kazunori& Ishida, Yoji. Successful Use of Cyclophosphamide as an Add-On Therapy for Multiple Myeloma Patients with Acquired Resistance to Bortezomib or Lenalidomide. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-488368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488368