Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease : The Atherosclerosis Risk in Communities (ARIC) Study
Joint Authors
Kucharska-Newton, Anna M.
Heiss, Gerardo
Pankow, James S.
Monda, Keri L.
Köttgen, Anna
Boerwinkle, Eric
Bielinski, Suzette J.
Rosamond, Wayne D.
Rea, Thomas D.
North, Kari E.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We examined the association of variation in the type 2 diabetes risk-conferring TCF7L2 gene with the risk of incident coronary heart disease (CHD) among the lean, overweight, and obese members of the Atherosclerosis Risk in Communities (ARIC) Study cohort.
Cox proportional hazard regression analyses were performed using a general model, with the major homozygote as the reference category.
For 9,865 whites, a significant increase in the risk of CHD was seen only among lean ( BMI<25 kg/m2) individuals homozygous for the T allele of the TCF7L2 rs7903146 gene risk variant (hazard ratio 1.42; 95% CI 1.03,1.97; P=.01).
No association was found among 3,631 blacks, regardless of BMI status.
An attenuated hazard ratio was observed among the nondiabetic ARIC cohort members.
This study suggests that body mass modifies the association of the TCF7L2 rs7903146 T allele with CHD risk.
American Psychological Association (APA)
Kucharska-Newton, Anna M.& Monda, Keri L.& Bielinski, Suzette J.& Boerwinkle, Eric& Rea, Thomas D.& Rosamond, Wayne D.…[et al.]. 2010. Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease : The Atherosclerosis Risk in Communities (ARIC) Study. Journal of Obesity،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-488369
Modern Language Association (MLA)
Kucharska-Newton, Anna M.…[et al.]. Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease : The Atherosclerosis Risk in Communities (ARIC) Study. Journal of Obesity No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-488369
American Medical Association (AMA)
Kucharska-Newton, Anna M.& Monda, Keri L.& Bielinski, Suzette J.& Boerwinkle, Eric& Rea, Thomas D.& Rosamond, Wayne D.…[et al.]. Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease : The Atherosclerosis Risk in Communities (ARIC) Study. Journal of Obesity. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-488369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488369