![](/images/graphics-bg.png)
Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors
Joint Authors
Sakurada, Mutsumi
Suehara, Yoshiyuki
Orita, Hajime
Kushida, Tomoyuki
Ito, Tomoaki
Maekawa, Hiroshi
Sato, Koichi
Kubota, Daisuke
Wada, Ryo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Despite complete resection of gastrointestinal stromal tumors (GIST), recurrent and/or metastatic disease occurs, often depending on the grade of malignancy.
As such, markers are needed that accurately predict patients at high risk for recurrence.
Previously our group reported Pfetin as a prognostic biomarker for GIST.
In order to create an approach for predicting risk of recurrence, we incorporated Pfetin expression with clinicopathological data to produce a predictive model.
Object.
Forty-five patients with localized primary GIST were treated with complete gross surgical resection surgically at our institution between 1995 and 2010 were included.
The majority of tumors originated in the stomach (38 cases), as well as small intestine (6 cases) and rectum (1 case).
Method.
(1) We performed retrospective analysis of the connection between Pfetin expression, clinicopathological data, and incidences of recurrence, using bivariate and multivariate analyses.
(2) The reactivity of the monoclonal antibody against Pfetin was examined by immunohistochemistry.
Pfetin.
We have reported Pfetin, identified microarray technology, and compared between statistically different GISTs for good and poor prognoses and for prognostic marker.
Results.
There were 7 cases of recurrences.
(1) By univariate analysis, tumor size, mitoses, exposure to abdominal cavity, and complete tumor removal predicted risk of recurrence.
(2) Pfetin-negative cases were significantly related to recurrence (P = 0.002).
Conclusions.
This analysis demonstrates that lack of Pfetin expression is an additional predictor of recurrence in resected GIST.
Further study may determine the role of this variable added to the current predictive model for selection of adjuvant therapy.
American Psychological Association (APA)
Orita, Hajime& Ito, Tomoaki& Kushida, Tomoyuki& Sakurada, Mutsumi& Maekawa, Hiroshi& Wada, Ryo…[et al.]. 2014. Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors. BioMed Research International،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-488376
Modern Language Association (MLA)
Orita, Hajime…[et al.]. Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors. BioMed Research International No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-488376
American Medical Association (AMA)
Orita, Hajime& Ito, Tomoaki& Kushida, Tomoyuki& Sakurada, Mutsumi& Maekawa, Hiroshi& Wada, Ryo…[et al.]. Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-488376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488376