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Myosin Binding Protein-C Slow : An Intricate Subfamily of Proteins
Joint Authors
Kontrogianni-Konstantopoulos, Aikaterini
Ackermann, Maegen A.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Myosin binding protein C (MyBP-C) consists of a family of thick filament associated proteins.
Three isoforms of MyBP-C exist in striated muscles: cardiac, slow skeletal, and fast skeletal.
To date, most studies have focused on the cardiac form, due to its direct involvement in the development of hypertrophic cardiomyopathy.
Here we focus on the slow skeletal form, discuss past and current literature, and present evidence to support that: (i) MyBP-C slow comprises a subfamily of four proteins, resulting from complex alternative shuffling of the single MyBP-C slow gene, (ii) the four MyBP-C slow isoforms are expressed in variable amounts in different skeletal muscles, (iii) at least one MyBP-C slow isoform is preferentially found at the periphery of M-bands and (iv) the MyBP-C slow subfamily may play important roles in the assembly and stabilization of sarcomeric M- and A-bands and regulate the contractile properties of the actomyosin filaments.
American Psychological Association (APA)
Ackermann, Maegen A.& Kontrogianni-Konstantopoulos, Aikaterini. 2010. Myosin Binding Protein-C Slow : An Intricate Subfamily of Proteins. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-488391
Modern Language Association (MLA)
Ackermann, Maegen A.& Kontrogianni-Konstantopoulos, Aikaterini. Myosin Binding Protein-C Slow : An Intricate Subfamily of Proteins. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-488391
American Medical Association (AMA)
Ackermann, Maegen A.& Kontrogianni-Konstantopoulos, Aikaterini. Myosin Binding Protein-C Slow : An Intricate Subfamily of Proteins. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-488391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488391