Ruscogenin Ameliorates Experimental Nonalcoholic Steatohepatitis via Suppressing Lipogenesis and Inflammatory Pathway
Joint Authors
Wu, Ming-Chang
Liou, Shorong-Shii
Liu, I-Min
Chang, Chia Ju
Lu, Hung-Jen
Yang, Cheng
Tzeng, Thing-Fong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of the study was to investigate the protective effects of ruscogenin, a major steroid sapogenin in Ophiopogon japonicus, on experimental models of nonalcoholic steatohepatitis.
HepG2 cells were exposed to 300 μmol/l palmitic acid (PA) for 24 h with the preincubation of ruscogenin for another 24 h.
Ruscogenin (10.0 μmol/l) had inhibitory effects on PA-induced triglyceride accumulation and inflammatory markers in HepG2 cells.
Male golden hamsters were randomly divided into five groups fed a normal diet, a high-fat diet (HFD), or a HFD supplemented with ruscogenin (0.3, 1.0, or 3.0 mg/kg/day) by gavage once daily for 8 weeks.
Ruscogenin alleviated dyslipidemia, liver steatosis, and necroinflammation and reversed plasma markers of metabolic syndrome in HFD-fed hamsters.
Hepatic mRNA levels involved in fatty acid oxidation were increased in ruscogenin-treated HFD-fed hamsters.
Conversely, ruscogenin decreased expression of genes involved in hepatic lipogenesis.
Gene expression of inflammatory cytokines, chemoattractive mediator, nuclear transcription factor-(NF-) κB, and α-smooth muscle actin were increased in the HFD group, which were attenuated by ruscogenin.
Ruscogenin may attenuate HFD-induced steatohepatitis through downregulation of NF-κB-mediated inflammatory responses, reducing hepatic lipogenic gene expression, and upregulating proteins in β-oxidation pathway.
American Psychological Association (APA)
Lu, Hung-Jen& Tzeng, Thing-Fong& Liou, Shorong-Shii& Chang, Chia Ju& Yang, Cheng& Wu, Ming-Chang…[et al.]. 2014. Ruscogenin Ameliorates Experimental Nonalcoholic Steatohepatitis via Suppressing Lipogenesis and Inflammatory Pathway. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-488457
Modern Language Association (MLA)
Lu, Hung-Jen…[et al.]. Ruscogenin Ameliorates Experimental Nonalcoholic Steatohepatitis via Suppressing Lipogenesis and Inflammatory Pathway. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-488457
American Medical Association (AMA)
Lu, Hung-Jen& Tzeng, Thing-Fong& Liou, Shorong-Shii& Chang, Chia Ju& Yang, Cheng& Wu, Ming-Chang…[et al.]. Ruscogenin Ameliorates Experimental Nonalcoholic Steatohepatitis via Suppressing Lipogenesis and Inflammatory Pathway. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-488457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488457