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Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture
Joint Authors
Ciotti, Maria Teresa
Nori, Stefania Lucia
Rocco, Maria Luisa
Florenzano, Fulvio
Manni, Luigi
Aloe, Luigi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-21
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Diabetic polyneuropathy (DPN), characterized by early hyperalgesia and increased nerve growth factor (NGF), evolves in late irreversible neuropathic symptoms with reduced NGF support to sensory neurons.
Electroacupuncture (EA) modulates NGF in the peripheral nervous system, being effective for the treatment of DPN symptoms.
We hypothesize that NGF plays an important pathogenic role in DPN development, while EA could be useful in the therapy of DPN by modulating NGF expression/activity.
Diabetes was induced in rats by streptozotocin (STZ) injection.
One week after STZ, EA was started and continued for three weeks.
NGF system and hyperalgesia-related mediators were analyzed in the dorsal root ganglia (DRG) and in their spinal cord and skin innervation territories.
Our results show that four weeks long diabetes increased NGF and NGF receptors and deregulated intracellular signaling mediators of DRG neurons hypersensitization; EA in diabetic rats decreased NGF and NGF receptors, normalized c-Jun N-terminal and p38 kinases activation, decreased transient receptor potential vanilloid-1 ion channel, and possibly activated the nuclear factor kappa-light-chain-enhancer of activated B cells (Nf-κB).
In conclusion, NGF signaling deregulation might play an important role in the development of DPN.
EA represents a supportive tool to control DPN development by modulating NGF signaling in diabetes-targeted neurons.
American Psychological Association (APA)
Nori, Stefania Lucia& Rocco, Maria Luisa& Florenzano, Fulvio& Ciotti, Maria Teresa& Aloe, Luigi& Manni, Luigi. 2013. Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-488467
Modern Language Association (MLA)
Nori, Stefania Lucia…[et al.]. Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-488467
American Medical Association (AMA)
Nori, Stefania Lucia& Rocco, Maria Luisa& Florenzano, Fulvio& Ciotti, Maria Teresa& Aloe, Luigi& Manni, Luigi. Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-488467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488467