Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma : A Case Report and Review of the Literature
Joint Authors
Alaiz, Helena
Frade, Maria Jesus
Nunes, Albertina
Bogalho, Isabel
Gomes da Silva, Maria
Moita, Filipa
Parreira, Joana
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-21
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hypereosinophilia, either clonal or reactive, has been described in association with multiple hematological malignancies.
We describe a case of a patient presenting with hypereosinophilia that evolved into T-cell lymphoblastic lymphoma.
Complete remission was achieved with chemotherapy; however, hypereosinophilia recurred 5 months later in association with myeloblastic bone marrow infiltration and without evidence of lymphoblastic lymphoma relapse.
Cytogenetic analysis of the bone marrow showed a complex translocation involving chromosomes 7, 12, and 16.
A rearrangement of ETV6 gene (12p13) was demonstrated by FISH studies, thus confirming the clonality of this population.
The association of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia has been described in disorders with FGFR1 rearrangements.
We hypothesize that other clonal eosinophilic disorders lacking this rearrangement could behave in a similar fashion through different pathogenic mechanisms.
American Psychological Association (APA)
Moita, Filipa& Bogalho, Isabel& Alaiz, Helena& Parreira, Joana& Frade, Maria Jesus& Nunes, Albertina…[et al.]. 2013. Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma : A Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-488470
Modern Language Association (MLA)
Moita, Filipa…[et al.]. Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma : A Case Report and Review of the Literature. Case Reports in Hematology No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-488470
American Medical Association (AMA)
Moita, Filipa& Bogalho, Isabel& Alaiz, Helena& Parreira, Joana& Frade, Maria Jesus& Nunes, Albertina…[et al.]. Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma : A Case Report and Review of the Literature. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-488470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488470