Changes in Maternal Glucose Metabolism after the Administration of Dexamethasone for Fetal Lung Development
Joint Authors
Zhaoxia, Liang
Qin, Fang
Yun, Chai
Danqing, Chen
Yuanyuan, Chen
Jian Yun, Xu
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Aims.
Antenatal dexamethasone administration for fetal lung development may impair maternal glucose tolerance.
In this study, we investigated whether glucose and insulin levels differed among singleton and twin pregnancies and pregnancies with impaired glucose tolerance (IGT) after treatment with dexamethasone.
Methods.
Singleton pregnancies, twin pregnancies, and pregnancies with IGT between 28 and 33 weeks of gestation whose mothers were treated with dexamethasone were enrolled in this study.
Exclusion criteria included gestational hypertension, diabetes, renal disorders, and infectious diseases.
The fasting plasma glucose and insulin levels were checked before administration and 24 h, 48 h, and 72 h after treatment was completed.
Results.
Mean glucose levels were significantly higher in the twin pregnancy and IGT groups at 24 h and 48 h after the administration of dexamethasone than those in the singleton pregnancy group (P<0.05).
Although there was no significant difference in glucose levels before administration and 72 h after dexamethasone administration among the three groups, insulin levels in the IGT group were significantly higher (P<0.05).
Insulin levels in the singleton pregnancy group at 24 h and 48 h after treatment were significantly lower than in the twin and IGT groups.
Conclusion.
The effects on maternal fasting blood glucose and insulin levels of dexamethasone administrated to promote fetal lung maturation correlated with embryo number and the presence of IGT.
American Psychological Association (APA)
Jian Yun, Xu& Zhaoxia, Liang& Yun, Chai& Qin, Fang& Yuanyuan, Chen& Danqing, Chen. 2012. Changes in Maternal Glucose Metabolism after the Administration of Dexamethasone for Fetal Lung Development. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-488477
Modern Language Association (MLA)
Jian Yun, Xu…[et al.]. Changes in Maternal Glucose Metabolism after the Administration of Dexamethasone for Fetal Lung Development. International Journal of Endocrinology No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-488477
American Medical Association (AMA)
Jian Yun, Xu& Zhaoxia, Liang& Yun, Chai& Qin, Fang& Yuanyuan, Chen& Danqing, Chen. Changes in Maternal Glucose Metabolism after the Administration of Dexamethasone for Fetal Lung Development. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-488477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488477