Sex Differences in Constitutive Autophagy
Joint Authors
Calvo, Ana Cristina
Osta, Rosario
Zaragoza, Pilar
Oliván, Sara
Manzano, Raquel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Sex bias has been described nowadays in biomedical research on animal models, although sexual dimorphism has been confirmed widely under pathological and physiological conditions.
The main objective of our work was to study the sex differences in constitutive autophagy in spinal cord and skeletal muscle tissue from wild type mice.
To examine the influence of sex on autophagy, mRNA and proteins were extracted from male and female mice tissues.
The expressions of microtubule-associated protein 1 light chain 3 (LC3) and sequestosome 1 (p62), markers to monitor autophagy, were analyzed at 40, 60, 90, and 120 days of age.
We found significant sex differences in the expression of LC3 and p62 in both tissues at these ages.
The results indicated that sex and tissue specific differences exist in constitutive autophagy.
These data underlined the need to include both sexes in the experimental groups to minimize any sex bias.
American Psychological Association (APA)
Oliván, Sara& Calvo, Ana Cristina& Manzano, Raquel& Zaragoza, Pilar& Osta, Rosario. 2014. Sex Differences in Constitutive Autophagy. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-488479
Modern Language Association (MLA)
Oliván, Sara…[et al.]. Sex Differences in Constitutive Autophagy. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-488479
American Medical Association (AMA)
Oliván, Sara& Calvo, Ana Cristina& Manzano, Raquel& Zaragoza, Pilar& Osta, Rosario. Sex Differences in Constitutive Autophagy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-488479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488479