Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma Eyes

Abstract EN

Purpose.

To investigate the effects of nipradilol on retrobulbar hemodynamics.

Methods.

We investigated normal and normal-tension glaucoma (NTG) eyes.

Topical nipradilol (one eye) and placebo eye drops (fellow eye) were instilled for 1 week in volunteers.

Nipradilol was also instilled in NTG patients.

Ultrasound color Doppler imaging for the posterior vessels was performed before, 2 hr, 1 week (for normal), and at 4 weeks (for NTG).

Results.

In normal eyes, there were significant decreases in the resistance index (RI) for the temporal short posterior ciliary arteries (PCA) at 2 hr and for the ophthalmic arteries at 1 week.

There were no significant changes in the placebo-treated eyes.

In the NTG eyes, there was a significant decrease in the RI for the central retinal artery, nasal, and temporal PCA at 2 hr and 4 weeks.

Conclusion.

Short-term observations found that nipradilol increased the ocular blood flow in normal and NTG eyes.