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Hyperplastic Polyps Are Innocuous Lesions in Hereditary Nonpolyposis Colorectal Cancers
Joint Authors
Lalloo, F.
Speake, D.
Hill, J.
Evans, D. Gareth
McMahon, R. F. T.
O'Sullivan, J.
Source
International Journal of Surgical Oncology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
To compare methylation profiles, protein expression, and microsatellite instability (MSI) of sporadic, HNPCC, and familial hyperplastic polyps (HPs).
Methods.
Methylation-specific PCR (MSP) and pyrosequencing assessed p16, MGMT, hMLH-1, MINT 1, and MINT 31 methylation.
IHC (Immunohistochemistry) assessed Ki67, CK20, hMLH-1, hMSH-2, and hMSH-6 protein expression.
MSI analysis was performed on those polyps with adequate DNA remaining.
Results.
124 HPs were identified 78 sporadic, 21 HNPCC, 25 familial, and the HNPCC group demonstrated no significant differences in overall methylation (P=.186 Chi2).
The familial group demonstrated significantly less over all methylation levels (P=.004 Chi2).
Conclusions.
HPs that occur in HNPCC have no more worrying features at a molecular level than those patients with HPs in a sporadic setting.
American Psychological Association (APA)
Speake, D.& O'Sullivan, J.& Evans, D. Gareth& Lalloo, F.& Hill, J.& McMahon, R. F. T.. 2011. Hyperplastic Polyps Are Innocuous Lesions in Hereditary Nonpolyposis Colorectal Cancers. International Journal of Surgical Oncology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-488510
Modern Language Association (MLA)
Speake, D.…[et al.]. Hyperplastic Polyps Are Innocuous Lesions in Hereditary Nonpolyposis Colorectal Cancers. International Journal of Surgical Oncology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-488510
American Medical Association (AMA)
Speake, D.& O'Sullivan, J.& Evans, D. Gareth& Lalloo, F.& Hill, J.& McMahon, R. F. T.. Hyperplastic Polyps Are Innocuous Lesions in Hereditary Nonpolyposis Colorectal Cancers. International Journal of Surgical Oncology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-488510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488510