Mauritia flexuosa Presents In Vitro and In Vivo Antiplatelet and Antithrombotic Activities
Joint Authors
Rodríguez-Pérez, Wilson
Fuentes, Eduardo
Palomo, Iván
Forero-Doria, Oscar
Alarcón, Marcelo
Navarrete, Simón
Guzmán, Luis
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Fruit from the palm Mauritia flexuosa is one of the most important species in Peru, Venezuela, Brazil, Colombia, Bolivia, and Guyana.
The present study aimed to investigate the antiplatelet and antithrombotic activities of oil extracted from Mauritia flexuosa.
The fatty acid contents were determined by gas chromatography—mass spectrometry.
Oil extract of peel of Mauritia flexuosa was extracted by soxhlet extraction.
The oil extract inhibited platelet secretion and aggregation induced by ADP, collagen, and TRAP-6 by a concentration-dependent way (0.1 to 1 mg/mL) without the participation of the adenylyl cyclase pathway and diminished platelet rolling and firm adhesion under flow conditions.
Furthermore, the oil extract induced a marked increase in the rolling speed of leukocytes retained on the platelet surface, reflecting a reduction of rolling and less adhesion.
At the concentrations used, the oil extract significantly decreased platelet release of sP-selectin, an atherosclerotic-related inflammatory mediator.
Oil extract inhibited thrombus growth at the same concentration as that of aspirin, a classical reference drug.
Finally, the data presented herein also demonstrate for the first time to our knowledge the protective effect of oil extracted from Mauritia flexuosa on platelet activation and thrombosis formation.
American Psychological Association (APA)
Fuentes, Eduardo& Rodríguez-Pérez, Wilson& Guzmán, Luis& Alarcón, Marcelo& Navarrete, Simón& Forero-Doria, Oscar…[et al.]. 2013. Mauritia flexuosa Presents In Vitro and In Vivo Antiplatelet and Antithrombotic Activities. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-488521
Modern Language Association (MLA)
Fuentes, Eduardo…[et al.]. Mauritia flexuosa Presents In Vitro and In Vivo Antiplatelet and Antithrombotic Activities. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-488521
American Medical Association (AMA)
Fuentes, Eduardo& Rodríguez-Pérez, Wilson& Guzmán, Luis& Alarcón, Marcelo& Navarrete, Simón& Forero-Doria, Oscar…[et al.]. Mauritia flexuosa Presents In Vitro and In Vivo Antiplatelet and Antithrombotic Activities. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-488521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488521