Cryptic Transcription and Early Termination in the Control of Gene Expression
Joint Authors
Porrua, Odil
Libri, Domenico
Colin, Jessie
Source
Genetics Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recent studies on yeast transcriptome have revealed the presence of a large set of RNA polymerase II transcripts mapping to intergenic and antisense regions or overlapping canonical genes.
Most of these ncRNAs (ncRNAs) are subject to termination by the Nrd1-dependent pathway and rapid degradation by the nuclear exosome and have been dubbed cryptic unstable transcripts (CUTs).
CUTs are often considered as by-products of transcriptional noise, but in an increasing number of cases they play a central role in the control of gene expression.
Regulatory mechanisms involving expression of a CUT are diverse and include attenuation, transcriptional interference, and alternative transcription start site choice.
This review focuses on the impact of cryptic transcription on gene expression, describes the role of the Nrd1-complex as the main actor in preventing nonfunctional and potentially harmful transcription, and details a few systems where expression of a CUT has an essential regulatory function.
We also summarize the most recent studies concerning other types of ncRNAs and their possible role in regulation.
American Psychological Association (APA)
Colin, Jessie& Libri, Domenico& Porrua, Odil. 2011. Cryptic Transcription and Early Termination in the Control of Gene Expression. Genetics Research International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-488534
Modern Language Association (MLA)
Colin, Jessie…[et al.]. Cryptic Transcription and Early Termination in the Control of Gene Expression. Genetics Research International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-488534
American Medical Association (AMA)
Colin, Jessie& Libri, Domenico& Porrua, Odil. Cryptic Transcription and Early Termination in the Control of Gene Expression. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-488534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488534