The Role of Bioactive Lipids in Stem Cell Mobilization and Homing : Novel Therapeutics for Myocardial Ischemia
Joint Authors
Karapetyan, Anush V.
Klyachkin, Yuri M.
Ratajczak, Mariusz Z.
Abdel-Latif, Ahmed
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Despite significant advances in medical therapy and interventional strategies, the prognosis of millions of patients with acute myocardial infarction (AMI) and ischemic heart disease (IHD) remains poor.
Currently, short of heart transplantation with all of its inherit limitations, there are no available treatment strategies that replace the infarcted myocardium.
It is now well established that cardiomyocytes undergo continuous renewal, with contribution from bone marrow (BM)-derived stem/progenitor cells (SPCs).
This phenomenon is upregulated during AMI by initiating multiple innate reparatory mechanisms through which BMSPCs are mobilized towards the ischemic myocardium and contribute to myocardial regeneration.
While a role for the SDF-1/CXCR4 axis in retention of BMSPCs in bone marrow is undisputed, its exclusive role in their mobilization and homing to a highly proteolytic microenvironment, such as the ischemic/infarcted myocardium, is currently being challenged.
Recent evidence suggests a pivotal role for bioactive lipids in the mobilization of BMSPCs at the early stages following AMI and their homing towards ischemic myocardium.
This review highlights the recent advances in our understanding of the mechanisms of stem cell mobilization, provides newer evidence implicating bioactive lipids in BMSPC mobilization and differentiation, and discusses their potential as therapeutic agents in the treatment of IHD.
American Psychological Association (APA)
Klyachkin, Yuri M.& Karapetyan, Anush V.& Ratajczak, Mariusz Z.& Abdel-Latif, Ahmed. 2014. The Role of Bioactive Lipids in Stem Cell Mobilization and Homing : Novel Therapeutics for Myocardial Ischemia. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-488540
Modern Language Association (MLA)
Klyachkin, Yuri M.…[et al.]. The Role of Bioactive Lipids in Stem Cell Mobilization and Homing : Novel Therapeutics for Myocardial Ischemia. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-488540
American Medical Association (AMA)
Klyachkin, Yuri M.& Karapetyan, Anush V.& Ratajczak, Mariusz Z.& Abdel-Latif, Ahmed. The Role of Bioactive Lipids in Stem Cell Mobilization and Homing : Novel Therapeutics for Myocardial Ischemia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-488540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488540