Hypothesis : The Role of Sterols in Autism Spectrum Disorder
Joint Authors
Tierney, Elaine
Lee, Ryan W. Y.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A possible role for sterols in the development of autism spectrum disorder (ASD) has not been proven, but studies in disorders of sterol biosynthesis, chiefly Smith-Lemli-Opitz syndrome (SLOS), enable hypotheses on a causal relationship to be discussed.
Advances in genetic technology coupled with discoveries in membrane physiology have led to renewed interest for lipids in the nervous system.
This paper hypothesizes on the role of sterol dysfunction in ASD through the framework of SLOS.
Impaired sonic hedgehog patterning, alterations in membrane lipid rafts leading to abnormal synaptic plasticity, and impaired neurosteroid synthesis are discussed.
Potential therapeutic agents include the development of neuroactive steroid-based agents and enzyme-specific drugs.
Future investigations should reveal the specific mechanisms underlying sterol dysfunction in neurodevelopmental disorders by utilizing advanced imaging and molecular techniques.
American Psychological Association (APA)
Lee, Ryan W. Y.& Tierney, Elaine. 2011. Hypothesis : The Role of Sterols in Autism Spectrum Disorder. Autism Research and Treatment،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-488541
Modern Language Association (MLA)
Lee, Ryan W. Y.& Tierney, Elaine. Hypothesis : The Role of Sterols in Autism Spectrum Disorder. Autism Research and Treatment No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-488541
American Medical Association (AMA)
Lee, Ryan W. Y.& Tierney, Elaine. Hypothesis : The Role of Sterols in Autism Spectrum Disorder. Autism Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-488541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-488541